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Mechanically Robust, Softening Shape Memory Polymer Probes for Intracortical Recording.

Allison M Stiller¹, Joshua O Usoro¹, Jennifer Lawson¹

¹Department of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.

|July 8, 2020

Summary

This summary is machine-generated.

Researchers developed novel shape memory polymer (SMP) microelectrode arrays (MEAs) for brain implants. These flexible neural devices enable easier surgical implantation and robust chronic recordings without insertion aids.

Keywords:

intracortical microelectrode arrays robust shape memory polymer softening

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Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

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Area of Science:

Biomaterials Science
Neuroscience
Medical Devices

Background:

Intracortical microelectrode arrays (MEAs) are crucial for neural interfacing but are often made from stiff materials like silicon, leading to fragility and surgical challenges.
Existing polymer-based MEAs can be mechanically unstable, necessitating insertion aids during implantation.
These limitations hinder the widespread clinical and basic research applications of MEAs.

Purpose of the Study:

To design and fabricate intracortical MEAs using a novel shape memory polymer (SMP) substrate.
To overcome the limitations of current MEAs by creating a device that is stiff for handling but flexible after implantation.
To evaluate the chronic performance and robustness of these SMP-based MEAs in vivo.

Main Methods:

Fabrication of intracortical MEAs from a shape memory polymer (SMP) substrate.
Characterization of the polymer's mechanical properties, demonstrating a transition from a stiff state at room temperature to a softened state (20 MPa) post-implantation.
In vivo implantation in rat cortex for chronic neural recordings and electrochemical measurements over 16 weeks.

Main Results:

The SMP-based MEAs were successfully implanted without the need for insertion aids due to their tunable mechanical properties.
Chronic neural recordings and electrochemical measurements were maintained for 16 weeks in the rat cortex.
The devices demonstrated robustness against physical deformation, indicating suitability for surgical procedures.

Conclusions:

Shape memory polymer (SMP) microelectrode arrays offer a promising solution for overcoming the mechanical challenges associated with neural implant fabrication and implantation.
These novel MEAs facilitate easier surgical implementation and enable stable, long-term neural recording.
The developed SMP-based MEAs represent an advantageous advancement for neural interfacing applications in both research and clinical settings.