Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

269
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
269

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fibre phantom generation using FibreSimulator: an open-source Python tool.

Journal of synchrotron radiation·2026
Same author

The ErbB-tyrosine kinase inhibitor, neratinib, has anti-inflammatory effects in multimorbidity by increasing macrophage efferocytosis via the upregulation of MerTK.

Journal of inflammation (London, England)·2026
Same author

A Case Report: Drug-Induced Liver Injury from Prolonged Topical Application of Noni (<i>Morinda citrifolia</i>).

Journal of investigative medicine high impact case reports·2026
Same author

TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques.

Nature communications·2026
Same author

Dual phase high temperature Si<sub>3</sub>N<sub>4</sub>/Al(Ti)N films with tunable thermal conductivity.

Nature communications·2025
Same author

Anti-progestin therapy targets hallmarks of breast cancer risk.

Nature·2025

Related Experiment Video

Updated: Dec 15, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.1K

X-ray Micro-Computed Tomography: An Emerging Technology to Analyze Vascular Calcification in Animal Models.

Samantha J Borland1, Julia Behnsen2, Nick Ashton1

  • 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

International Journal of Molecular Sciences
|July 8, 2020
PubMed
Summary

Vascular calcification, linked to cardiovascular disease, can be analyzed using X-ray micro-computed tomography (µCT). This non-destructive 3D imaging technique offers precise quantification and localization of calcification in animal models.

Keywords:
correlative microscopyhistologymicro-CTmouse modelsvascular calcification

More Related Videos

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

2.0K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

873

Related Experiment Videos

Last Updated: Dec 15, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.1K
Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

2.0K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

873

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Imaging

Background:

  • Vascular calcification is a significant risk factor for cardiovascular morbidity and mortality.
  • It is prevalent in chronic kidney disease, diabetes, and atherosclerosis.
  • Current analysis methods like 2D histology and colorimetric assays have limitations.

Purpose of the Study:

  • To review rodent models for studying vascular calcification.
  • To critically assess current quantification techniques.
  • To introduce X-ray micro-computed tomography (µCT) as an advanced analysis tool.

Main Methods:

  • Review of rodent models for vascular calcification.
  • Assessment of 2D histology and o-cresolphthalein assay.
  • Examination of X-ray micro-computed tomography (µCT) for 3D analysis.
  • Discussion of correlative microscopy workflows combining µCT with histology and proteomics.

Main Results:

  • X-ray micro-computed tomography (µCT) enables non-destructive, 3D quantification and localization of vascular calcification.
  • µCT allows for simultaneous analysis of calcification volume and load in intact vessels.
  • Correlative microscopy workflows provide multifaceted data on calcification and signaling.

Conclusions:

  • X-ray micro-computed tomography (µCT) is a powerful complementary tool for studying vascular calcification in animal models.
  • The technique offers advantages in precision and detail compared to traditional methods.
  • Future applications may include real-time in vivo visualization and measurement of vascular calcification.