An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts...

Area of Science:

• Nephrology
• Genetics
• Translational Medicine

Background:

• Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of end-stage renal disease.
• Current treatments for ADPKD are limited, with only one moderately effective option available.
• Despite significant research progress, the exact pathophysiological mechanisms of ADPKD are not fully understood.

Purpose of the Study:

• To provide a comprehensive overview of the various cellular and animal models used in ADPKD research.
• To critically evaluate the advantages and limitations of each model in deciphering ADPKD's complex mechanisms.
• To guide researchers in selecting appropriate tools for studying ADPKD.

Main Methods:

• Review of existing literature on ADPKD models.
• Analysis of commonly utilized cellular models (e.g., cell cultures, organoids).
• Evaluation of prevalent animal models (e.g., mouse, rat, zebrafish models).

Main Results:

• Various models exist, including cell cultures, organoids, and animal models, each offering unique insights.
• No single model perfectly replicates the complexity of human ADPKD.
• Models differ in their ability to recapitulate specific aspects of ADPKD, such as cyst formation and progression.

Conclusions:

• Understanding the advantages and limitations of each ADPKD model is crucial for effective research.
• The selection of an appropriate model depends on the specific research question being addressed.
• Continued development and refinement of ADPKD models are necessary to advance therapeutic strategies.