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Middle East Respiratory Syndrome Coronavirus (MERS-CoV): State of the Science

Ahmed Mostafa1, Ahmed Kandeil1, Mahmoud Shehata1

  • 1Center of Scientific Excellence for Influenza Viruses, Environmental Research Division, National Research Centre (NRC), Cairo 12622, Egypt.

Microorganisms
|July 8, 2020
PubMed

Insights

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has a high fatality rate. This review summarizes MERS-CoV

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Coronaviruses are a large viral family causing diseases from common colds to severe respiratory syndromes.
  • Three zoonotic coronaviruses have crossed into humans since 2003, causing significant mortality.
  • Middle East Respiratory Syndrome Coronavirus (MERS-CoV) exhibits a high case fatality rate (CFR) of approximately 35%, exceeding SARS-CoV (10%) and SARS-CoV-2 (6%).

Purpose of the Study:

  • To systematically review and summarize the current scientific understanding of MERS-CoV.
  • To consolidate information on MERS-CoV virology, origin, and epidemiology.
  • To explore MERS-CoV's zoonotic transmission and potential interventions.

Main Methods:

  • Systematic literature review.
  • Synthesis of existing research on MERS-CoV.
  • Analysis of MERS-CoV virology, epidemiology, transmission, and therapeutics.

Main Results:

  • MERS-CoV represents a significant public health threat due to its high CFR.
  • Understanding MERS-CoV's origin and transmission is crucial for control.
  • Research into therapeutic and prophylactic interventions is ongoing.

Conclusions:

  • MERS-CoV remains a critical focus in coronavirus research due to its severity.
  • Comprehensive knowledge of MERS-CoV is essential for managing future outbreaks.
  • Further research into MERS-CoV interventions is vital for mitigating its impact.
Keywords:
MERS-CoVcoronavirusepidemiologyzoonotic disease

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