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Related Experiment Videos

Effect of prostaglandin E on immune function in multiple animal models.

J P Waymack1, R W Yurt

  • 1Shriners Burn Institute, Cincinnati Unit.

Archives of Surgery (Chicago, Ill. : 1960)
|November 1, 1988
PubMed
Summary

Prostaglandin E (PGE) may not be as immunosuppressive in animal models as previously thought. This study found a PGE derivative improved survival in some models and did not impair cell-mediated immunity in others.

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Area of Science:

  • Immunology
  • Trauma Research

Background:

  • Prostaglandin E (PGE) is implicated in immunosuppression after trauma and burns.
  • In vitro studies show PGE impairs leukocyte functions.

Purpose of the Study:

  • To investigate the in vivo effects of a novel long-acting PGE derivative (16,16-dimethyl-PGE) on immune function.
  • To determine if PGE's immunosuppressive effects observed in vitro translate to in vivo models.

Main Methods:

  • Administration of 16,16-dimethyl-PGE in various animal models including burn sepsis and Escherichia coli peritonitis.
  • Assessment of mortality, survival times, neutrophil migration, and cell-mediated immunity (including lymphocyte function).

Main Results:

  • The PGE derivative did not affect mortality in burn sepsis models.

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  • It improved survival in an E. coli peritonitis model.
  • Neutrophil migration was impaired at lower dosages, but cell-mediated immunity was not impaired and lymphocyte function improved at certain dosages in a rat burn model.

    • Conclusions:

    • PGE's immunosuppressive role in vivo may be less pronounced than suggested by in vitro studies.
    • The long-acting PGE derivative demonstrated varied effects on immune function and survival across different models.