Related Experiment Video
Updated: Dec 15, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Lack of Evidence for an Association between IL-17F Rs763780 Polymorphism and Pulmonary Tuberculosis
1Department of Emergency Medicine, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.
Abstract:
The relationship between the interleukin-17F (IL-17F) rs763780 polymorphism and tuberculosis (TB) has been a source of debate. The potential association between the IL-17F rs763780 polymorphism and TB was investigated using a meta-analysis of case-control studies, which were obtained using the EMBASE, PubMed, CNKI, Scopus, and Web of Science databases. Heterogeneity across studies was evaluated, and summary odds ratios and 95% confidence intervals were computed to estimate a summary effect size using either a fixed-effects or random-effects model. Eight eligible studies comprising nine comparisons for the IL-17F rs763780 polymorphism (3824 cases and 3787 controls) were obtained for this meta-analysis. Although a significant relationship between IL-17F rs763780 and TB susceptibility was observed using the allele genetic model (odds ratio = 1.34, 95% confidence interval = 1.04-1.74), there was high heterogeneity among the studies (I2 = 79%, P=0.0001). The stratified analyses by race, type of tuberculosis, and Hardy-Weinberg equilibrium suggested that the IL-17F rs763780 polymorphism was not associated with risk of pulmonary tuberculosis and the heterogeneity disappeared. Hardy-Weinberg equilibrium is the main cause of the heterogeneity. No evidence was found through this meta-analysis that suggested an association between the IL-17F rs763780 polymorphism and risk of pulmonary tuberculosis.
More Related Videos
Related Concept Videos
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Single Nucleotide Polymorphisms-SNPs

