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Updated: Dec 15, 2025

Study of Protein-protein Interactions in Autophagy Research
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Published on: September 9, 2017

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Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.

Hersh K Bhargava1,2, Keisuke Tabata3, Jordan M Byck1,2

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.

Proceedings of the National Academy of Sciences of the United States of America
|July 8, 2020
PubMed
Summary

Rubicon inhibits autophagy by binding Rab7-GTP. Understanding this interaction via crystal structure reveals the Rubicon RH domain as a therapeutic target for enhancing autophagy.

Keywords:
Rab GTPaseautophagycrystal structure

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