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Related Experiment Videos

Glomerular hematuria in diabetics.

J B Lopes de Faria1, L A Moura, S R Lopes de Faria

  • 1Nephrology Division, Escola Paulista de Medicina, São Paulo, Brazil.

Clinical Nephrology
|September 1, 1988
PubMed
Summary

Glomerular hematuria (GH) affects 13.4% of diabetes mellitus (DM) patients, significantly associated with male sex, elevated creatinine, and proteinuria. GH prevalence increases with longer DM duration and retinopathy.

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Area of Science:

  • Nephrology
  • Endocrinology
  • Diabetology

Background:

  • Diabetes mellitus (DM) is a complex metabolic disorder with significant renal implications.
  • Hematuria, particularly glomerular hematuria (GH), can be an indicator of underlying kidney pathology in diabetic patients.
  • Understanding the prevalence and clinical associations of GH is crucial for early diagnosis and management of diabetic nephropathy.

Purpose of the Study:

  • To evaluate the prevalence and origin of glomerular hematuria (GH) in outpatients with diabetes mellitus (DM).
  • To determine the clinical and laboratory features associated with GH in this population.
  • To investigate the significance of GH in the context of diabetic kidney disease.

Main Methods:

  • Study population: 320 outpatients with diabetes mellitus (DM).

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  • Assessment of hematuria, proteinuria (24-hour urine collection), red blood cell casts, serum creatinine, and clinical data.
  • Renal biopsy performed in a subset of patients to confirm diabetic glomerulosclerosis.

    • Main Results:

    • Glomerular hematuria (GH) was present in 13.4% of the studied diabetic population.
    • GH showed significant associations with male sex (p < 0.001), high serum creatinine (p = 0.0002), and 24-hour proteinuria > 150 mg (p < 0.001).
    • GH was more frequent in males with DM duration > 10 years (p < 0.001) and those with retinopathy (p < 0.001).

    Conclusions:

    • Glomerular hematuria (GH) is a notable finding in a subset of diabetes mellitus (DM) patients.
    • GH is significantly linked to male gender, advanced kidney dysfunction (high creatinine), and proteinuria in DM.
    • The presence of GH warrants further investigation for diabetic nephropathy, especially in long-standing DM with retinopathy.