Evaluation of Vaccine Candidates against Leptospirosis using Golden Syrian Hamsters
Karen V Evangelista1,2, Kristel Lourdault3
1Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA. karen.evangelista@va.gov.
Abstract:
Leptospirosis is a major public health problem, especially in developing countries. Current vaccine studies focus on identifying Leptospira proteins that elicit protective immunity. Here, we describe a method to assess recombinant proteins for their ability to protect hamsters from fatal infection against Leptospira and to provide sterilizing immunity.
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