Related Experiment Video
Updated: Dec 15, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Primary headache in childhood associated with psychiatric disturbances: an update
1Department Clinical and Experimental Medicine, Child and Adolescent Neuropsychiatry, University of Catania, Catania, Italy. ppavone@unict.it.
Insights
Pediatric primary headaches show a significant link with anxiety and depression in children. While not associated with most other behavioral disorders, these findings mirror adult patterns.
Area of Science:
- Pediatric Neurology
- Child Psychiatry
- Behavioral Science
Background:
- Primary headache disorders are common in children, with migraine being a significant concern.
- Understanding associated conditions is crucial for comprehensive pediatric care.
- Behavioral comorbidities require further investigation in pediatric headache populations.
Purpose of the Study:
- To determine the frequency of behavioral comorbidities in children with primary headaches.
- To investigate associations between primary headaches and specific conditions like ADHD, learning disabilities, tics, anxiety, depression, and OCD.
- To compare comorbidity rates in children with headaches versus a control group.
Main Methods:
- A study involving 475 children (aged 4-14) diagnosed with primary headache.
- Direct interviews with children and parents to gather data on behavioral conditions.
- A control group of 475 children without headache or neurological conditions, matched for demographics.
Main Results:
- A significant association was found between primary headaches and anxiety (p<0.001).
- A significant association was observed between primary headaches and depression (p<0.001).
- Overall, behavioral disorders were more prevalent in children with headaches compared to controls (p<0.001).
Conclusions:
- Primary headaches in children are not significantly associated with most common behavioral conditions.
- A notable association exists between pediatric primary headaches and anxiety and depression.
- These findings align with observations of similar associations in adult populations.
Objective:
Primary headache disorders in children are one of the most prominent topics in the pediatric neurology literature. However, there are many unsolved aspects, including the conditions associated with migraine. The present study aims to report on the frequency of behavioral comorbidities in the setting of primary headache in childhood.
Patients And Methods:
In this study, we enlisted 475 children (290 males and 185 females; ratio 1.6:1), aged 4 to 14 years, who were affected by primary headache. In direct interviews, children and parents gave information on the association of their headache with, attention-deficit/hyperactivity disorder, learning disabilities, tics, anxiety, depression, and obsessive-compulsive disorder. Other 475 children with no history of headache or recognized neurological conditions were matched for age, sex, race, and socioeconomic status and were used as controls.
Results:
A significant association of primary headache was found with anxiety and depression (p-value <0.001); overall, behavioral disorders were more common in children who experienced headache than in controls (p-value <0.001).
Conclusions:
Primary headache in children is not associated with most of the common behavioral conditions. On the contrary, there was a significant association with anxiety and depression, as reported in adults.
More Related Videos
09:57Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
Related Concept Videos
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Mania and Antimanic Drugs: Overview
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Nightmares and Night Terrors
Nightmares...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Oppositional Defiant Disorder
Diagnostic Criteria and...