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Anti-inflammatory activity of a new compound from Vernonia amygdalina
Thi Xuan Thu Nguyen1, Duc Long Dang2, Van Quang Ngo3
1Faculty of Chemical Engineering, University of Science and Technology, The University of Danang, Da Nang, Vietnam.
Abstract:
In this study, a new stigmastane, vernonioside V, was isolated from the ethanol extract of leaves of Vernonia amygdalina along with a known flavonoid, cynaroside, and then anti-inflammatory activity of isolated compounds was investigated. The result showed that vernonioside V at concentration of 30 µg/mL strongly inhibited TNFα, IL-6, and IL-8 inflammatory cytokine production. Furthermore, LPS-induced supreoxide generation in Raw 264.7 were significantly reduced by pre-treatment of vernonioside V (30 µg/mL). These data indicated that vernonioside V had inhibitory activities on pro-inflammatory cytokine in LPS-stimulated Raw 264.7 through reactive oxygen species (ROS).
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