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The severity of executive dysfunction among different PD-MCI subtypes

Constantinos Kormas1, Ioannis Zalonis1, Ioannis Evdokimidis1

  • 1First Department of Neurology, National and Kapodistrian University of Athens, Aeginition Hospital, Athens, Greece.

Applied Neuropsychology. Adult
|July 8, 2020
PubMed

Insights

Executive dysfunction severity differs across Parkinson's disease (PD) with mild cognitive impairment (MCI) subtypes. The PD-MCI executive plus visuospatial group showed greater impairment than other subtypes, impacting clinical management.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder.
  • Mild cognitive impairment (MCI) is common in early PD.
  • Executive dysfunction is a key feature of PD-MCI.

Purpose of the Study:

  • To investigate the severity of executive dysfunction in distinct early-stage PD-MCI subtypes.
  • To compare executive function performance across PD-MCI subtypes.

Main Methods:

  • Neuropsychological assessment of 65 early-stage PD patients.
  • Categorization into three PD-MCI subtypes: executive, executive plus memory, and executive plus visuospatial.
  • Evaluation of executive functions using Trail Making Test-Part B (TMT-B) and Stroop Neuropsychological Screening Test (SNST).

Main Results:

  • Significant differences in TMT-B and SNST performance were found among the three PD-MCI subtypes.
  • The PD-MCI executive plus visuospatial group exhibited poorer performance on executive measures compared to the other two groups.
  • No significant performance differences were noted between the PD-MCI executive and PD-MCI executive plus memory groups.

Conclusions:

  • The severity of executive dysfunction varies significantly across different PD-MCI subtypes.
  • Findings support the dual syndrome hypothesis in PD.
  • Assessing executive impairment severity is crucial for effective clinical management of PD patients.
Keywords:
Executive functionsParkinson’s diseaseinhibitory controlmental flexibilitymild cognitive impairment

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