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Related Experiment Video

Updated: Dec 15, 2025

Author Spotlight: Utilizing Venoplasty Balloon Model in Rodents to Simulate Surgical Interventions for Deep Veins

Author Spotlight: Utilizing Venoplasty Balloon Model in Rodents to Simulate Surgical Interventions for Deep Veins

Published on: May 24, 2024

Drug-coated balloons: Technical and clinical progress.

Huiying Ang^1,2, Tobias R Koppara³, Salvatore Cassese³

¹National Heart Centre Singapore, Singapore.

Vascular Medicine (London, England)

|July 8, 2020

Summary

Drug-coated balloons (DCB) offer a nonstent option for atherosclerotic lesions, showing promise in coronary artery disease and peripheral artery disease. Further randomized trials are needed to confirm long-term safety and clinical value, especially for below-the-knee interventions.

Keywords:

coronary artery disease (CAD)drug-coated balloons percutaneous coronary interventions peripheral artery disease (PAD)peripheral interventions

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Last Updated: Dec 15, 2025

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Published on: February 5, 2021

Monitoring the Wall Mechanics During Stent Deployment in a Vessel

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Published on: May 8, 2012

Area of Science:

Cardiovascular Medicine
Interventional Cardiology
Biomaterials Science

Background:

Drug-eluting stents (DES) are the standard for percutaneous coronary interventions.
Drug-coated balloons (DCB) provide a nonstent alternative for treating atherosclerotic lesions.
DCB technology is evolving with potential applications beyond traditional stent use.

Purpose of the Study:

To review current drug-coated balloon (DCB) technologies and clinical progress.
To update on the clinical data of DCB in coronary artery disease (CAD) and peripheral artery disease (PAD).
To assess the potential and limitations of DCB in various vascular interventions.

Main Methods:

Systematic review of current DCB technologies.
Analysis of clinical data from studies on DCB for CAD and PAD.
Evaluation of safety and efficacy outcomes reported in the literature.

Main Results:

DCB shows potential in treating in-stent restenosis (ISR) and de novo lesions in CAD.
DCB use in bifurcation side branches demonstrates safety with good outcomes.
Clinical outcomes for DCB in femoropopliteal arteries are conflicting; role in below-the-knee (BTK) disease is uncertain.

Conclusions:

DCB represent a viable nonstent option for specific atherosclerotic lesions.
Further randomized controlled trials are necessary to establish definitive clinical value and long-term safety, particularly for PAD and BTK interventions.
DCB technology continues to advance, offering alternatives to stenting in interventional cardiology.