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Multiple organ failure during interleukin-2 administration and LAK cells infusion
J P Sculier1, D Bron, N Verboven
1Service de Médecine, Institut Jules Bordet, Centre des Tumeurs de l'Université, Libre de Bruxelles, Belgium.
Intensive Care Medicine
|January 1, 1988
Summary
Adoptive immunotherapy shows promise for cancer treatment but can cause severe capillary leak syndrome. This case highlights critical complications like coma and renal failure, necessitating intensive care unit support.
Area of Science:
- Oncology
- Immunotherapy
- Critical Care Medicine
Background:
- Adoptive immunotherapy represents a novel and promising approach for cancer treatment.
- This therapy, however, is frequently associated with significant toxicities, primarily capillary leak syndrome.
Observation:
- A patient with metastatic hypernephroma developed severe complications following adoptive immunotherapy.
- These complications included coma, acute renal failure, pulmonary edema, severe acidosis, cardiac arrhythmias, and venous thrombosis.
Findings:
- The patient's severe, multi-systemic complications underscore the potential dangers of adoptive immunotherapy.
- Capillary leak syndrome was the main toxicity observed, leading to critical illness.
Implications:
- Critical care specialists must be prepared for the complex management of patients undergoing adoptive immunotherapy.
- Awareness of potential severe side effects is crucial for timely and effective intensive care unit (ICU) supportive care.