Mathematical Modeling Can Advance Wound Healing Research

Significance: For over 30 years, there has been sustained interest in the development of mathematical models for investigating the complex mechanisms underlying each stage of the wound healing process. Despite the immense associated challenges, such models have helped usher in a paradigm shift in wound healing research. Recent Advances: In this article, we review contributions in the field that span epidermal, dermal, and corneal wound healing, and treatments of nonhealing wounds. The recent influence of mathematical models on biological experiments is detailed, with a focus on wound healing assays and fibroblast-populated collagen lattices. Critical Issues: We provide an overview of the field of mathematical modeling of wound healing, highlighting key advances made in recent decades, and discuss how such models have contributed to the development of improved treatment strategies and/or an enhanced understanding of the tightly regulated steps that comprise the healing process. Future Directions: We detail some of the open problems in the field that could be addressed through a combination of theoretical and/or experimental approaches. To move the field forward, we need to have a common language between scientists to facilitate cross-collaboration, which we hope this review can support by highlighting progress to date.