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Risk Factors for Perinatal Arterial Ischemic Stroke: A Case-Control Study.
Daniela Munoz1, María José Hidalgo1, Fernanda Balut1
1Department of Pediatric Neurology and Psychiatry, San Borja Arriarán Hospital, University of Chile, Santiago, Chile.
Cell Medicine
|July 8, 2020
Summary
Primiparity, emergency cesarean section, birth asphyxia, and low Apgar scores are key risk factors for perinatal arterial ischemic stroke (PAIS). Further research is needed to fully understand this condition.
Area of Science:
- Neonatal Neurology
- Pediatric Stroke Research
- Perinatal Medicine
Background:
- Perinatal arterial ischemic stroke (PAIS) is a significant cause of neonatal complications.
- The precise pathophysiology and risk factors for PAIS remain incompletely understood.
Purpose of the Study:
- To retrospectively investigate potential risk factors associated with diagnosed cases of PAIS.
Main Methods:
- A case-control study analyzing clinical data of PAIS patients.
- Matching PAIS cases with two healthy controls based on gestational age.
- Employing univariable and multivariable analyses to identify risk factors.
Main Results:
- The study included 40 PAIS patients, with a male predominance (66.7%).
- Medial cerebral artery involvement (87.5%) and left hemisphere preference (62.5%) were common.
- Multivariate analysis identified primiparity, emergency cesarean section, birth asphyxia, and Apgar score ≤7 as significant risk factors.
Conclusions:
- Primiparity, emergency cesarean section, birth asphyxia, and low Apgar scores are significantly linked to PAIS.
- Additional research with larger cohorts and extended follow-up is necessary to elucidate PAIS risk factors.
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