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Updated: Dec 15, 2025

In Vivo Gene Delivery into Mouse Mammary Epithelial Cells Through Mammary Intraductal Injection
Published on: February 10, 2023
In vivo gene delivery mediated by non-viral vectors for cancer therapy
Reza Mohammadinejad1, Ali Dehshahri2, Vijay Sagar Madamsetty3
1Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Abstract:
Gene therapy by expression constructs or down-regulation of certain genes has shown great potential for the treatment of various diseases. The wide clinical application of nucleic acid materials dependents on the development of biocompatible gene carriers. There are enormous various compounds widely investigated to be used as non-viral gene carriers including lipids, polymers, carbon materials, and inorganic structures. In this review, we will discuss the recent discoveries on non-viral gene delivery systems. We will also highlight the in vivo gene delivery mediated by non-viral vectors to treat cancer in different tissue and organs including brain, breast, lung, liver, stomach, and prostate. Finally, we will delineate the state-of-the-art and promising perspective of in vivo gene editing using non-viral nano-vectors.
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