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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
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Polypeptide-based self-healing hydrogels: Design and biomedical applications.

Lili Cai1, Sa Liu2, Jianwei Guo1

  • 1School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.

Acta Biomaterialia
|July 8, 2020
PubMed
Summary
This summary is machine-generated.

Polypeptide-based self-healing hydrogels offer enhanced material longevity and biocompatibility. This review highlights their fabrication methods and diverse biomedical applications, paving the way for advanced "smart" materials.

Keywords:
Antibacterial and wound healingBioadhesion and hemostasisDrug deliveryEncapsulation of cellsNoncovalent interactionsPolypeptideReversible covalent crosslinkingSelf-healing hydrogelsTissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Self-healing hydrogels extend material lifespan by autonomously repairing damage.
  • Polypeptides, derived from amino acids, offer biocompatibility, biodegradability, and low immunogenicity.
  • These properties make polypeptides ideal for developing advanced self-healing hydrogels for biomedical uses.

Purpose of the Study:

  • To review recent advancements in polypeptide-based self-healing hydrogels.
  • To summarize fabrication strategies and biomedical applications.
  • To highlight future challenges and opportunities in this field.

Main Methods:

  • Review of fabrication strategies including host-guest interactions, hydrogen bonding, electrostatic interactions, supramolecular self-assembly, reversible covalent bonds, and molecular multi-interactions.
  • Summary of biomedical applications: drug delivery, tissue engineering, 3D bioprinting, wound healing, and hemostasis.
  • Analysis of recent research trends over the past five years.

Main Results:

  • Polypeptide-based hydrogels can be fabricated using diverse crosslinking methods.
  • These hydrogels show significant promise in various biomedical applications.
  • The field is rapidly evolving with ongoing innovations.

Conclusions:

  • Polypeptide-based self-healing hydrogels are highly suitable for biomedical applications due to their inherent properties.
  • Continued research into fabrication and application will drive innovation in smart biomaterials.
  • These materials hold great potential for improving patient outcomes and therapeutic strategies.