Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Organ-specific redox and trace element modulation and hematological adaptation following hyperbaric oxygenation and physical activity in rats.

Frontiers in medicine·2026

Same author

Factors of modern lifestyle influencing gait pattern alterations in elementary school children: a mini review.

Frontiers in pediatrics·2026

Same author

The B7-H3/CD3 immune phenotype identifies prognostic subgroups in neuroblastoma.

Frontiers in immunology·2026

Same author

Job and Employee Satisfaction Among Healthcare Staff in a Tertiary Hospital: A Cross-Sectional Study.

Journal of nursing management·2026

Same author

Estradiol-to-oocyte ratio as a prognostic biomarker of assisted reproductive outcomes in women with polycystic ovary syndrome: The impact of LH activity.

Women's health (London, England)·2026

Same author

Isotretinoin-Induced Hematuria in Acne Patients: Frequency, Risk Factors, and Management Recommendations from a Single-Center Study.

Dermatology practical & conceptual·2026

Search research articles

Related Experiment Video

Updated: Dec 15, 2025

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

Trace elements in different tissues in aging rats.

Aleksandar Rakic¹, Ivan D Milovanovich², Alexander M Trbovich¹

¹Department of Pathological Physiology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)

|July 8, 2020

Summary

Aging significantly alters trace element levels and their correlations in rat tissues, particularly in kidneys and testicles. These findings highlight the link between environmental exposure, aging, and health, emphasizing the need for further research.

Keywords:

Aging Animal model Healthy tissue Trace elements

More Related Videos

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Related Experiment Videos

Last Updated: Dec 15, 2025

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Area of Science:

Environmental Health
Toxicology
Gerontology

Background:

Trace elements (TE) link environment, lifestyle, and body's homeostasis.
Non-essential (toxic) elements are associated with various diseases.
Age-related changes in TE levels and their correlations are not fully understood.

Purpose of the Study:

To identify differences in TE levels between young and old Wistar rats.
To investigate age-related differences in TE correlations within and between key tissues.
To explore the impact of aging on essential and non-essential element profiles.

Main Methods:

Analysis of 16 elements in blood and tissues (kidney, liver, heart, testicles) of young (10 weeks) and old (36 months) Wistar rats.
Inductively coupled plasma mass spectrometry (ICP-MS) for TE determination.
Comparison of TE levels and inter-element correlations between age groups.

Main Results:

Toxic elements (As, Hg, Cd) were significantly higher in old rats across examined tissues.
Kidney and liver tissues showed the most TE correlations in old and young rats, respectively.
Arsenic exhibited the most correlations with other elements in both age groups.

Conclusions:

Significant age-related differences in TE levels were observed, especially in kidneys and testicles.
Findings suggest a connection between TE, aging, and physiological changes.
Further research with broader tissue analysis and molecular methods is recommended to elucidate TE's role in aging.