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Child-Adult Transition in Sarcoidosis: A Series of 52 Patients

Simon Chauveau1,2, Florence Jeny1,2, Marie-Emeline Montagne3

  • 1AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France.

Journal of Clinical Medicine
|July 9, 2020
PubMed

Insights

Pediatric sarcoidosis often requires long-term treatment, with nearly half of patients needing it into adulthood. Approximately one-fifth of these individuals experience severe sarcoidosis complications later in life.

Area of Science:

  • Pediatric Rheumatology
  • Pulmonology
  • Immunology

Background:

  • Pediatric sarcoidosis is a rare, often severe condition with limited long-term follow-up data.
  • Understanding the adult outcomes of childhood-onset sarcoidosis is crucial for effective management.

Purpose of the Study:

  • To evaluate the long-term evolution and adult outcomes of sarcoidosis that began in childhood.
  • To identify factors influencing disease progression and treatment response in pediatric sarcoidosis survivors.

Main Methods:

  • Retrospective and prospective study of 52 patients with pediatric-onset sarcoidosis (diagnosis ≤15 years old) followed for at least three years.
  • Analysis of clinical data at presentation and long-term outcomes in adulthood, including disease severity, relapses, and treatment adverse events.

Main Results:

  • A median follow-up of 11.5 years revealed that 21.2% of patients had severe sarcoidosis in adulthood.
  • Relapses predominantly occurred during treatment tapering (84.5%).
  • Long-term corticosteroid therapy (median 5 years) led to mostly mild adverse events (35.3%), with severe events in 3.8%.

Conclusions:

  • Pediatric-onset sarcoidosis frequently necessitates prolonged treatment, impacting nearly half of patients into adulthood.
  • A significant proportion of individuals with childhood-onset sarcoidosis face severe disease consequences in adulthood, highlighting the need for ongoing monitoring and management.

Keywords:
childreninterstitial lung diseasesarcoidosistransition of care

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