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Pharmacologic modulation of acute ocular inflammation. I. Adenosine
G E Marak1, Y de Kozak, J P Faure
1Center for Sight, Georgetown University, Washington, D.C.
Ophthalmic Research
|January 1, 1988
Abstract:
Modulation of signal transduction at the surface of inflammatory cells appears to influence acute inflammation. Adenosine, a well-known chemical messenger, inhibits the production of superoxide by stimulated neutrophils. In experimental allergic uveitis induced by sensitization with retinal 's' antigen, treatment with adenosine produced a marked reduction in the expected inflammation.