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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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MicroRNAs01:22

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Updated: Dec 15, 2025

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
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Regulatory noncoding RNAs and the major histocompatibility complex.

Nilesh Sunil Chitnis1, Mengkai Shieh1, Dimitri Monos2

  • 1Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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|July 9, 2020
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Noncoding RNAs (ncRNAs) from the Major Histocompatibility Complex (MHC) and other genomic regions are crucial for regulating immune genes. Their dysregulation impacts health, highlighting their importance in cellular homeostasis.

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Area of Science:

  • Genomics
  • Immunology
  • Molecular Biology

Background:

  • The Major Histocompatibility Complex (MHC) is a critical genomic region on chromosome 6, housing key immune genes like Human Leukocyte Antigens (HLAs).
  • Emerging research indicates that noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), originating from the MHC and elsewhere, significantly influence cellular regulation.

Purpose of the Study:

  • To explore the role of ncRNAs, specifically miRNAs and lncRNAs, in the regulation of MHC genes.
  • To understand the broader impact of genomic ncRNAs on immune-related MHC protein expression.

Main Methods:

  • The abstract does not specify methods, but implies analysis of ncRNA function within the MHC region.
  • Review and synthesis of current research on ncRNA regulation of immune genes.

Main Results:

  • Noncoding RNAs from the MHC and other genomic areas play a significant role in cellular regulation.
  • ncRNA regulation of MHC genes is vital for immune function, healthy pregnancy, and cellular homeostasis.

Conclusions:

  • The study of ncRNAs within the MHC is a nascent but critical research area.
  • Dysregulation of the ncRNA network associated with MHC genes can lead to severe health issues and disease.