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Updated: Dec 15, 2025
10:37
Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
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UBE2O Promotes Progression and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma
Xiyu Chen1,2,3, Shuiting Zhang1,2,3, Chao Liu1,2,3
1Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.
Oncotargets and Therapy
|July 9, 2020
Summary
UBE2O is an oncogene that promotes head and neck squamous cell carcinoma (HNSCC) progression. It enhances cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), leading to worse survival prognosis in HNSCC patients.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- UBE2O, a ubiquitin-conjugating enzyme, is implicated in various human malignancies.
- Its specific role in head and neck squamous cell carcinoma (HNSCC) was previously unknown.
Purpose of the Study:
- To investigate the role of UBE2O in HNSCC progression.
- To elucidate the underlying mechanisms of UBE2O's function in HNSCC.
Main Methods:
- Analyzed UBE2O expression in HNSCC patient data (TCGA and primary cohort).
- Assessed UBE2O's functional impact on HNSCC cells in vitro (viability, proliferation, migration, invasion).
- Evaluated UBE2O's effect on HNSCC tumor growth in vivo using xenograft models.
Main Results:
- UBE2O expression is significantly elevated in HNSCC tissues and correlates with poor survival.
- UBE2O overexpression promotes HNSCC cell proliferation, migration, and invasion.
- UBE2O induces epithelial-mesenchymal transition (EMT) and potentiates TGF-β1-induced EMT, enhancing HNSCC cell invasiveness.
- UBE2O knockout inhibits EMT, angiogenesis, and tumor growth in vivo.
Conclusions:
- UBE2O functions as an oncogene in HNSCC.
- UBE2O promotes malignant progression and EMT in HNSCC, highlighting its potential as a therapeutic target.
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