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Updated: Dec 15, 2025

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Acute progressing hepatic angiosarcoma: An autopsy case report.

Masaki Inoue1, Mio Matsumoto1, Yusuke Sakuhara2

  • 1Department of Gastroenterology, Sapporo Medical Center NTT EC, Minami 1-jo nishi 15-chome Chuo-ku, Sapporo 060-0061, Japan.

Radiology Case Reports
|July 9, 2020
PubMed
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This summary is machine-generated.

A rare case of hepatic angiosarcoma presented atypically in a middle-aged man with liver dysfunction. Autopsy confirmed the diagnosis after imaging and tumor markers were inconclusive.

Area of Science:

  • Hepatology
  • Oncology
  • Diagnostic Imaging

Background:

  • A man in his 50s with a history of heavy alcohol consumption and smoking presented with lower leg edema and abdominal distension.
  • Initial blood tests revealed hepatic dysfunction, thrombocytopenia, jaundice, hypoalbuminemia, and decreased coagulability.

Observation:

  • Elevated carbohydrate antigen 19-9 (CA19-9) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) tumor markers were noted.
  • Contrast-enhanced computed tomography (CT) and hepatic arteriography showed multiple liver masses with atypical hemangioma-like features and a "cotton wool" appearance.
  • Magnetic resonance imaging (MRI) revealed multiple mass-like lesions with characteristic signal intensities on T1-weighted and T2-weighted images.

Findings:

  • The imaging findings were atypical, hindering a definitive preoperative diagnosis.
Keywords:
Hepatic angiosarcomaHepatic hemangiomaHepatic tumor

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  • The patient experienced rapid worsening of hepatic failure.

    • Implications:

    • This case highlights the diagnostic challenges posed by atypical hepatic angiosarcoma.
    • Autopsy confirmed hepatic angiosarcoma as the cause of the patient's rapid decline and death.
    • Emphasizes the importance of considering rare diagnoses in complex liver disease presentations.