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Ultrasound-enhanced diffusion through isolated frog skin.

A J Mortimer1, B J Trollope, E J Villeneuve

  • 1National Research Council of Canada, Ottawa, Ontario.

Ultrasonics
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

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Ultrasound significantly enhances oxygen transport across frog skin. This study suggests the mechanism is not cavitation, even at higher intensities.

Area of Science:

  • Biophysics
  • Physiology

Background:

  • Oxygen transport across biological membranes is crucial for cellular respiration.
  • Understanding factors influencing transdermal oxygen diffusion is important for various physiological and medical applications.

Purpose of the Study:

  • To investigate the effect of continuous wave (c.w.) ultrasound on oxygen transport across excised frog abdominal skin.
  • To determine the relationship between ultrasound intensity and the rate of oxygen diffusion.
  • To explore the role of cavitation in ultrasound-mediated oxygen transport.

Main Methods:

  • Excised frog abdominal skin samples were mounted in an exposure chamber.
  • One side of the skin was exposed to oxygen-saturated Ringer's solution, while the other had low initial oxygen concentration.

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  • Samples were treated with ultrasound at varying intensities (1, 1.5, and 2 W cm-2 SATA c.w.).
  • Oxygen transport rates were measured under different ultrasound conditions, including variations in pulse length.

    • Main Results:

    • Ultrasound treatment increased the rate of oxygen transport across the frog skin at all tested intensities.
    • Observed increases in oxygen transport ranged from 38% at 1 W cm-2 to 55% at 2 W cm-2.
    • Varying pulse lengths (25-200 ms) at a constant average intensity did not significantly affect the transport rate, suggesting the mechanism is not primarily cavitation.

    Conclusions:

    • Ultrasound effectively enhances oxygen transport across biological tissues like frog skin.
    • The observed phenomenon is likely mediated by factors other than acoustic cavitation.
    • These findings have potential implications for therapeutic ultrasound applications aimed at improving tissue oxygenation.