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Updated: Dec 15, 2025

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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
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Ligandrol (LGD-4033)-Induced Liver Injury
Mary Barbara1,2, Sadhna Dhingra3, Ayse L Mindikoglu1,2
1Section of Gastroenterology and Hepatology, Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine, Houston, TX.
ACG Case Reports Journal
|July 9, 2020
Abstract:
We described a 32-year-old man who developed severe drug-induced liver injury after using Ligandrol (LGD-4033). The diagnosis was confirmed by a liver biopsy that showed cholestatic hepatitis with a mild portal, periportal, and perisinusoidal fibrosis. Ligandrol is a selective androgen receptor modulator that is available over the counter and via the internet.

