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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Related Experiment Video

Updated: Dec 15, 2025

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
04:48

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

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Netarsudil-associated epithelial keratopathy.

Meera S Ramakrishnan1, Victoria M Addis1,2, Amanda Y Lehman1,2

  • 1Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 N. 39th Street, Philadelphia, PA, 19104, USA.

American Journal of Ophthalmology Case Reports
|July 9, 2020
PubMed
Summary
This summary is machine-generated.

Bullous epithelial keratopathy is a potential adverse effect of netarsudil eye drops. This finding was observed in two glaucoma patients using netarsudil, highlighting a new side effect to monitor.

Keywords:
Drug reactionGlaucomaKeratopathyNetarsudilRho-kinase inhibitors

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Netarsudil ophthalmic solution 0.02% (Rhopressa) is a novel rho-kinase inhibitor used to manage open-angle glaucoma and ocular hypertension.
  • Increasing use of netarsudil necessitates awareness of its potential adverse effects.

Observation:

  • Two cases of bullous epithelial keratopathy associated with netarsudil use are reported.
  • Patients presented with corneal epithelial bullae, conjunctival hyperemia, and keratic precipitates after initiating netarsudil treatment.

Findings:

  • Discontinuation of netarsudil led to the resolution of corneal edema and conjunctival hyperemia in both patients.
  • The observed bullous epithelial keratopathy represents a previously undocumented adverse effect of netarsudil.

Implications:

  • Ophthalmologists and patients should be aware of this potential side effect of netarsudil.
  • Further research may be needed to understand the mechanism and incidence of netarsudil-induced bullous epithelial keratopathy.