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The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...

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Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

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Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue

Huanhuan Liu¹, Mingli Lin², Xue Liu¹

¹School of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.

Bioactive Materials

|July 9, 2020

Summary

This study introduces a novel method to create bioactive collagen scaffolds by doping them with strontium or silver. These enhanced scaffolds promote bone growth, modulate immune responses, and fight bacterial infections for improved bone defect repair.

Keywords:

Bioactive elements Bone tissue engineering Collagen scaffold Synchronous self-assembly/mineralization

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Area of Science:

Biomaterials Science
Tissue Engineering
Nanotechnology

Background:

Pure collagen lacks osteoinductive, osteoimmunomodulatory, and antibacterial properties essential for bone defect repair.
Current strategies often fail to impart multiple desired bioactivities to collagen scaffolds simultaneously.

Purpose of the Study:

To develop a novel synchronous self-assembly/mineralization (SSM) method for doping bioactive elements into collagen.
To create multifunctional collagen scaffolds with enhanced osteogenesis, immunomodulation, and antibacterial properties.

Main Methods:

Utilized amorphous mineral nanoparticles (AMN) stabilized by carboxymethyl chitosan (CMC) and collagen under acidic conditions.
Achieved intrafibrillar mineralization via self-assembly and pH-induced mineralization, leading to crystal formation within collagen microfibrils.
Fabricated strontium-doped (Sr-CS) and silver-doped (Ag-CS) collagen scaffolds.

Main Results:

Sr-CS promoted rat bone marrow mesenchymal stromal cell (rBMSC) proliferation, osteogenic differentiation, and enhanced bone regeneration in vivo by modulating macrophage response.
Ag-CS demonstrated in vitro antibacterial activity against S. aureus and exhibited good cell/tissue compatibility.
The SSM method successfully doped bioactive elements into collagen, creating multifunctional scaffolds.

Conclusions:

The SSM model is a viable de novo strategy for creating bioactive collagen scaffolds.
These multifunctional scaffolds offer potential solutions for clinical challenges in bone defect treatment, including promoting osteogenesis, immune response modulation, and infection control.