Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

541
Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
541
Complexometric Titration: Overview00:39

Complexometric Titration: Overview

10.5K
Complexometric titration involves the formation of a complex by reacting a metal ion with one or more ligands. A visual indicator often detects the end point of a complexometric titration. It is added to the metal solution before the titration, forming a stable metal–indicator complex and imparting color to the solution. As the titration approaches the equivalence point, the excess of the added ligand displaces the indicator from the metal–indicator complex, releasing the free...
10.5K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

975
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
975

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functionalized Thiacalix[4]arenes as Dual Metal-Ion Extractants and Insecticidal Agents: Synthesis, Characterization, and Insecticidal Activity Against Spodoptera littoralis.

Chemistry & biodiversity·2026
Same author

Utilization Patterns and Barriers to Sodium-Glucose Cotransporter-2 Inhibitor Prescription in Patients with Heart Failure: Real-World Evidence from Saudi Arabia.

Cardiology and therapy·2026
Same author

Correction: Molecular and materials design for efficient solar energy conversion: a review of photochemical technologies.

RSC advances·2026
Same author

Magnetically recoverable activated carbon/CMC-β-cyclodextrin composite sponge for high-performance Cr(VI) adsorption, reduction, and sustainable wastewater treatment.

Scientific reports·2026
Same author

Innovative regioselective synthesis of dispiro[fluorene-9,3'-pyrazole-5',4″-pyrazolidines]: experimental and computational study.

RSC advances·2026
Same author

Photothermal carbon black coatings enable efficient solar-driven membrane distillation.

RSC advances·2026

Related Experiment Video

Updated: Dec 15, 2025

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
05:35

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Published on: January 17, 2020

7.8K

Combating Essential Metal Toxicity: Key Information from Optical Spectroscopy.

Saleh A Ahmed1,2, Md Nur Hasan3, Damayanti Bagchi3

  • 1Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, 21955 Makkah, Saudi Arabia.

ACS Omega
|July 9, 2020
PubMed
Summary

Curcumin effectively chelates iron, forming a complex with improved antioxidant activity. This iron-curcumin complex shows potential for treating iron toxicity and oxidative stress without generating harmful reactive oxygen species.

More Related Videos

Identification of Metal Oxide Nanoparticles in Histological Samples by Enhanced Darkfield Microscopy and Hyperspectral Mapping
12:19

Identification of Metal Oxide Nanoparticles in Histological Samples by Enhanced Darkfield Microscopy and Hyperspectral Mapping

Published on: December 8, 2015

12.8K
A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks
10:13

A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks

Published on: April 28, 2023

2.9K

Related Experiment Videos

Last Updated: Dec 15, 2025

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
05:35

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Published on: January 17, 2020

7.8K
Identification of Metal Oxide Nanoparticles in Histological Samples by Enhanced Darkfield Microscopy and Hyperspectral Mapping
12:19

Identification of Metal Oxide Nanoparticles in Histological Samples by Enhanced Darkfield Microscopy and Hyperspectral Mapping

Published on: December 8, 2015

12.8K
A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks
10:13

A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks

Published on: April 28, 2023

2.9K

Area of Science:

  • Biochemistry
  • Materials Science
  • Pharmacology

Background:

  • Excess essential metals cause cell injury and life-threatening diseases.
  • Current chelating agents have significant side effects, necessitating safer alternatives.
  • Curcumin's potential as a biocompatible chelating agent requires investigation.

Purpose of the Study:

  • To synthesize and characterize an iron-curcumin (Fe-Cur) complex.
  • To evaluate the iron-chelating properties and antioxidant activity of the Fe-Cur complex.
  • To elucidate the mechanism of action for potential therapeutic applications.

Main Methods:

  • Spectroscopic tools for characterization.
  • Synthesis of the iron-curcumin complex.
  • Femtosecond-resolved fluorescence studies.

Main Results:

  • Successful synthesis and characterization of the Fe-Cur complex.
  • Demonstrated improved antioxidant activity of the Fe-Cur complex.
  • Observed no significant reactive oxygen species generation under dark conditions.

Conclusions:

  • The Fe-Cur complex is a promising candidate for iron chelation therapy.
  • The complex exhibits dual activity: metal ion excretion and therapeutic agent for oxidative stress.
  • Electron transfer from ligand to metal is a key mechanism in its activity.