Related Experiment Video

Updated: Dec 15, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

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Intravenous Migraine Treatment in Children and Adolescents

Klaus Werner1, Sharoon Qaiser2, Marielle Kabbouche2

  • 1Division of Pediatric Neurology, Duke University Medical Center, Durham, NC, USA. klaus.werner@duke.edu.

Current Pain and Headache Reports
|July 9, 2020
PubMed

Insights

Pediatric migraine management in emergency departments often requires intravenous treatments. Current evidence is limited, highlighting the need for more high-quality pediatric studies on these headache therapies.

Area of Science:

  • Pediatric Neurology
  • Emergency Medicine
  • Pharmacology

Background:

  • Pediatric migraine is a prevalent, chronic, and debilitating neurological condition in children and adolescents.
  • Outpatient treatments for pediatric migraine are not consistently effective, necessitating emergency department interventions.
  • Intravenous (IV) migraine management is often required for acute headache relief in pediatric emergency settings.

Purpose of the Study:

  • To review current intravenous drug treatments for pediatric migraine in the emergency department.
  • To assess the existing evidence base for IV migraine therapies in children and adolescents.
  • To identify gaps in research and guide future studies in pediatric migraine management.

Main Methods:

  • A literature review of 19 studies was conducted.
  • Studies included prospective randomized double-blind, single-blinded randomized, prospective, and open-label randomized clinical trials.
  • The review focused on IV agents such as fluids, prochlorperazine, diphenhydramine, metoclopramide, dexamethasone, magnesium, valproate, propofol, and dihydroergotamine.

Main Results:

  • The majority of reviewed studies were retrospective, with limited overall study quality.
  • Only a small number of prospective and randomized controlled trials were identified.
  • No definitive conclusions could be drawn regarding the efficacy of specific IV treatments due to study limitations.

Conclusions:

  • The current evidence for intravenous migraine management in pediatric emergency departments is limited and of low quality.
  • High-quality, prospective, randomized controlled trials are essential to advance the field.
  • Collaboration among major pediatric headache institutions is crucial for conducting robust research and improving treatment strategies.
Abstract

Keywords:
Acute treatmentIntravenous treatmentPediatric migraineStatus migrainosus

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