Related Experiment Video
Updated: Dec 15, 2025
06:08
Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
Published on: March 11, 2017
10.9K
Optimising the absorption of medicines
1Department of Health Sciences, University of York, York, England.
Nursing Standard (Royal College of Nursing (Great Britain) : 1987)
|July 9, 2020
Summary
Understanding pharmacokinetic factors is crucial for nurses to safely administer medications. Adhering to the four principles of medicines optimisation ensures maximum therapeutic benefit and patient safety.
Area of Science:
- Pharmacology
- Clinical Nursing
Background:
- Medicine absorption is influenced by complex pharmacokinetic factors.
- Nurses need a thorough understanding of these factors for safe and effective patient care.
- The Royal Pharmaceutical Society outlines four key principles for medicines optimisation.
Purpose of the Study:
- To discuss pharmacokinetic factors affecting medicine absorption.
- To examine the four principles of medicines optimisation.
- To guide nurses on applying these principles for safe medication use.
Main Methods:
- Literature review of pharmacokinetic principles.
- Analysis of the Royal Pharmaceutical Society's medicines optimisation guidelines.
Main Results:
- Key pharmacokinetic variables influencing drug absorption identified.
- The four principles of medicines optimisation detailed.
- Practical applications for nurses highlighted.
Conclusions:
- Nurses can enhance patient safety and therapeutic outcomes by understanding pharmacokinetics.
- Implementing medicines optimisation principles is essential for effective drug therapy.
- Continuous learning in pharmacokinetics and optimisation is vital for nursing practice.
Related Concept Videos
01:22Factors Influencing Drug Absorption: Physicochemical Parameters
718
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
718
01:25Factors Influencing Drug Absorption: Disease States and Pharmacology
1.2K
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
1.2K
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
322
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
322
01:23Factors Influencing Drug Absorption: Anatomical Parameters
484
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
484
01:27Bioavailability Enhancement: Drug Permeability Enhancement
120
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
120
01:19Drug Absorption: Factors Affecting GI Absorption
5.6K
The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
5.6K