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Recent advances in higher order rotaxane architectures.

He-Ye Zhou¹, Qian-Shou Zong², Ying Han³

¹Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. cchen@iccas.ac.cn hanying463@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, China.

Chemical Communications (Cambridge, England)

|July 9, 2020

Summary

Synthesizing complex, higher order rotaxanes remains challenging but offers exciting applications in molecular machines. Recent advances focus on well-defined structures and stimuli-responsive molecular motion.

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Area of Science:

Supramolecular Chemistry
Materials Science

Background:

Archetypal [2]rotaxanes are well-established, but higher order rotaxanes present significant synthetic hurdles.
Higher order rotaxanes feature multiple interlocked molecular components, enabling complex architectures.

Purpose of the Study:

To review recent advancements in the synthesis of higher order rotaxanes.
To highlight diverse rotaxane architectures and their corresponding synthetic methodologies.
To discuss the stimuli-responsive molecular motion within these complex interlocked systems.

Main Methods:

Focus on template-directed synthesis strategies.
Description of various higher order rotaxane architectures.
Analysis of synthetic approaches for constructing complex rotaxanes.

Main Results:

Progress in achieving well-defined higher order rotaxane structures.
Demonstration of diverse synthetic routes for complex rotaxanes.
Exploration of stimuli-responsive behaviors in advanced rotaxane systems.

Conclusions:

Higher order rotaxanes are increasingly accessible through refined synthetic techniques.
These complex molecules are crucial for developing sophisticated artificial molecular machines.
Future research will likely focus on enhancing the complexity and functionality of rotaxane-based systems.