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Cell-mediated immune response in patients with type IIa, type IIb and type IV primary hyperlipoproteinaemia
S Antonaci1, E Jirillo, A R Garofalo
1Fisiopatologia Medica, University of Bari Medical School, Italy.
Cytobios
|January 1, 1988
Abstract:
Plasma lipoproteins inhibit immune function. Polymorphonuclear cell (PMN) and monocyte activities, and pokeweed mitogen (PWM)-driven B cell differentiation in patients with type IIa, type IIb and type IV primary hyperlipoproteinaemia were evaluated. Evidence is provided for a selective impairment of these functional capacities in type IIa and type IIb hyperlipoproteinaemic patients, while immune responsiveness is unaffected in type IV primary hyperlipoproteinaemia. The data suggest a specific immune dysfunction in patients with type IIa and type IIb primary hyperlipoproteinaemia.