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Updated: Dec 15, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

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Coronavirus Disease among Persons with Sickle Cell Disease, United States, March 20-May 21, 2020

Julie A Panepinto, Amanda Brandow, Lana Mucalo

    Emerging Infectious Diseases
    |July 9, 2020
    PubMed

    Insights

    Sickle cell disease (SCD) impacts Black or African American individuals, causing organ damage and shorter lives. A US registry found 69% of SCD patients were hospitalized and 7% died from COVID-19.

    Area of Science:

    • Hematology
    • Infectious Diseases
    • Public Health

    Background:

    • Sickle cell disease (SCD) disproportionately affects Black or African American populations in the US.
    • SCD can lead to severe multisystem organ damage and a reduced lifespan.
    • Understanding COVID-19 outcomes in SCD patients is critical due to potential disease severity.

    Purpose of the Study:

    • To analyze the impact of COVID-19 on individuals with sickle cell disease in the United States.
    • To determine hospitalization and mortality rates for SCD patients with COVID-19.

    Main Methods:

    • Data collected from an SCD-coronavirus disease case registry in the US.
    • Analysis of reported cases including hospitalization and death outcomes.
    • Descriptive statistics to summarize patient data.

    Main Results:

    • 178 individuals with SCD and COVID-19 were reported to the registry.
    • 69% (122) of these patients were hospitalized.
    • 7% (13) of these patients died.

    Conclusions:

    • COVID-19 poses a significant risk to individuals with sickle cell disease.
    • High rates of hospitalization and mortality underscore the vulnerability of the SCD population to COVID-19.
    • Further research and public health interventions are needed to protect this population.

    Keywords:
    COVID-19SARS-CoV-2SCDUnited Statescoronaviruscoronavirus diseasehemoglobinrespiratory diseasessevere acute respiratory syndrome coronavirus 2sickle cell diseaseviruseszoonoses

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