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Updated: Dec 15, 2025

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Published on: May 13, 2016
Ezrin promotes hepatocellular carcinoma progression by modulating glycolytic reprogramming
Xinyue Wang1,2, Nan Li3, Anna Han1,2
1Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China.
Ezrin protein promotes hepatocellular carcinoma (HCC) progression and metastasis by enhancing cell proliferation and reprogramming glucose metabolism. Targeting ezrin may offer a new strategy for HCC treatment and prognosis.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Ezrin (ERM protein) is linked to cancer progression.
- The role of ezrin in hepatocellular carcinoma (HCC) metastasis and glycolysis remains unclear.
Purpose of the Study:
- Investigate ezrin's role in HCC metastasis and glycolysis.
- Determine if ezrin is a prognostic marker for HCC.
Main Methods:
- Analyzed ezrin expression in HCC tissues.
- Conducted functional experiments on HCC cells (proliferation, EMT, angiogenesis).
- Measured glucose metabolism markers and effects of 2-deoxy-D-glucose (2-DG).
Main Results:
- Ezrin was upregulated in HCC tissues and correlated with aggressive features and poor prognosis.
- Ezrin overexpression promoted HCC cell proliferation, EMT, and angiogenesis.
- Ezrin regulated HCC glycolysis, and 2-DG affected ezrin-mediated HCC progression.
Conclusions:
- Ezrin is involved in HCC progression, metastasis, and glycolysis reprogramming.
- Ezrin may serve as a prognostic marker for hepatocellular carcinoma.
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