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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

8.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Related Experiment Video

Updated: Dec 15, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

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Autoimmune Conditions: Systemic Lupus Erythematosus.

Nguyet-Cam Vu Lam1

  • 1St. Luke's Family Medicine Residency, 2830 Easton Ave, Bethlehem, PA 18017.

FP Essentials
|July 9, 2020
PubMed
Summary

Systemic lupus erythematosus (SLE) is a complex autoimmune condition impacting multiple organ systems. Effective management involves hydroxychloroquine, low-dose glucocorticoids, and potentially immunosuppressants to improve outcomes and quality of life.

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease.
  • Diagnosis and management often involve rheumatology subspecialists.
  • Treatment aims to improve long-term outcomes, achieve remission, prevent organ damage, and enhance quality of life.

Purpose of the Study:

  • To outline the comprehensive management strategy for Systemic Lupus Erythematosus.
  • To emphasize the importance of regular disease activity assessment.
  • To detail recommended pharmacological interventions for SLE.

Main Methods:

  • Assessment of disease activity using validated instruments at baseline and follow-up.
  • Recommendation of hydroxychloroquine for all patients indefinitely unless contraindicated.

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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  • Utilization of low-dose glucocorticoids for symptom management.
  • Consideration of immunosuppressive drugs and biologics based on affected organ systems.

    • Main Results:

    • Hydroxychloroquine is a cornerstone therapy for all SLE patients.
    • Low-dose glucocorticoids effectively manage most SLE symptoms.
    • Immunosuppressants and biologics offer targeted treatment options for severe or specific organ involvement.

    Conclusions:

    • Comprehensive management of SLE requires a multidisciplinary approach.
    • Long-term treatment with hydroxychloroquine is crucial for SLE patients.
    • Tailored pharmacotherapy, including glucocorticoids, immunosuppressants, and biologics, is essential for optimal SLE patient outcomes.