Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.3K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.5K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.5K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

678
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
678
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

297
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
297
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.5K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nail Changes Following a Viral Infection.

American family physician·2019
See all related articles

Related Experiment Video

Updated: Dec 15, 2025

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
04:47

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice

Published on: October 27, 2023

1.6K

Autoimmune Conditions: Ankylosing Spondylitis.

Martha McGarey Metzgar1

  • 1St. Luke's Family Medicine Residency, 2830 Easton Ave, Bethlehem, PA 18017.

FP Essentials
|July 9, 2020
PubMed
Summary

Ankylosing spondylitis (AS) is a rare cause of back pain in young adults. Early diagnosis and treatment with NSAIDs, physical therapy, and lifestyle changes are crucial for managing this condition.

Area of Science:

  • Rheumatology
  • Immunology

Background:

  • Ankylosing spondylitis (AS) is an often-overlooked cause of inflammatory back pain in young adults.
  • Diagnosis is frequently delayed, necessitating awareness of key symptoms and risk factors.

Purpose of the Study:

  • To outline the diagnostic criteria and management strategies for ankylosing spondylitis.
  • To highlight the importance of early identification and multidisciplinary care.

Main Methods:

  • Review of diagnostic indicators including inflammatory back pain, family history, and related conditions.
  • Utilization of imaging (X-rays) and genetic testing (HLA-B27).
  • Application of the Assessment of SpondyloArthritis International Society (ASAS) criteria.

Main Results:

More Related Videos

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.8K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

837

Related Experiment Videos

Last Updated: Dec 15, 2025

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
04:47

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice

Published on: October 27, 2023

1.6K
Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.8K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

837
  • X-rays are the initial imaging choice; HLA-B27 testing aids diagnosis when sacroiliitis is absent.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are first-line therapy.
  • Tumor necrosis factor-alpha inhibitors and slow-acting antirheumatic drugs are subsequent treatment options.

Conclusions:

  • Early suspicion and diagnosis of AS are vital.
  • Management involves pharmacotherapy (NSAIDs, biologics, DMARDs), physical therapy, and lifestyle modifications.
  • Patients with AS face increased risks of complications like spinal fracture and associated conditions (uveitis, IBD, osteoporosis).