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Updated: Dec 15, 2025
09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
Published on: October 7, 2025
232
miR-655: A promising regulator with therapeutic potential
Hongxiang Li1, Jiale Zhang1, Yue Yang2
1Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.
Gene
|July 9, 2020
Summary
MicroRNA-655 (miR-655) plays a dual role in cancer, affecting cell growth and drug response. Its expression levels are linked to patient prognosis, highlighting its potential as a diagnostic and prognostic marker.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNA-655 (miR-655) is a small non-coding RNA with significant implications in human diseases.
- Its expression is dysregulated across numerous cancer types, showing down-regulation in 15+ cancers and up-regulation in acute myeloid leukemia (AML) and breast cancer (BC).
Purpose of the Study:
- To systematically analyze the biological pathways and molecular functions associated with miR-655 in cancer.
- To identify genes targeted by miR-655 and its upstream regulatory pathways, particularly in breast cancer.
- To evaluate the potential of miR-655 as a molecular marker for cancer diagnosis and prognosis.
Main Methods:
- Literature review and systematic analysis of existing research on miR-655.
- Identification and summarization of genes regulated by miR-655 in various cancers.
- Analysis of biological pathways and molecular functions linked to miR-655 target genes.
Main Results:
- miR-655-related genes are implicated in critical cancer processes including proliferation, migration, invasion, and apoptosis.
- These genes are also involved in angiogenesis, epithelial-mesenchymal transition (EMT), and oxidative stress.
- miR-655 influences drug efficacy through its targeted genes and is linked to patient prognosis.
Conclusions:
- miR-655 is a key regulator in cancer development and progression.
- Its dysregulation impacts multiple cancer hallmarks and therapeutic responses.
- miR-655 holds promise as a valuable biomarker for cancer diagnosis and prognosis.
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