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RIFM fragrance ingredient safety assessment, phenylethyl anthranilate, CAS Registry Number 133-18-6
Summary
Phenylethyl anthranilate safety was assessed across multiple endpoints. The material is not expected to be genotoxic, phototoxic, or a skin sensitizer, supporting its current use.
Area of Science:
- Chemical safety assessment
- Toxicology and risk evaluation
- Environmental safety standards
Background:
- Phenylethyl anthranilate is a chemical ingredient requiring comprehensive safety evaluation.
- Existing data and read-across approaches are utilized to assess potential risks.
Purpose of the Study:
- To evaluate the safety of phenylethyl anthranilate for its intended use.
- To determine potential risks related to genotoxicity, toxicity, sensitization, and environmental impact.
Main Methods:
- Genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety were assessed.
- Read-across data from cinnamyl anthranilate, phenethyl alcohol, and anthranilic acid were used.
- Specific safety thresholds like the Direct-to-Standard (DST) and Threshold of Toxicological Concern (TTC) were applied.
Main Results:
- Phenylethyl anthranilate is not expected to be genotoxic, phototoxic, or a photoallergen.
- Skin exposure is below the DST for non-reactive materials.
- Calculated Margin of Exposure (MOE) for repeated dose and developmental toxicity is >100.
- Environmental risk quotients (PEC/PNEC) are <1, indicating no PBT concern.
Conclusions:
- The safety assessment supports the current use of phenylethyl anthranilate.
- Phenylethyl anthranilate demonstrates an acceptable safety profile across evaluated toxicological and environmental endpoints.
