Related Experiment Video
Updated: Dec 15, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Cell Fate Determination of Lymphatic Endothelial Cells
1Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea.
Abstract:
The lymphatic vasculature, along with the blood vasculature, is a vascular system in our body that plays important functions in fluid homeostasis, dietary fat uptake, and immune responses. Defects in the lymphatic system are associated with various diseases such as lymphedema, atherosclerosis, fibrosis, obesity, and inflammation. The first step in lymphangiogenesis is determining the cell fate of lymphatic endothelial cells. Several genes involved in this commitment step have been identified using animal models, including genetically modified mice. This review provides an overview of these genes in the mammalian system and related human diseases.
Related Concept Videos
Lineage Commitment
Overview of the Vascular System
Determination
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Production of Formed Elements
Most HSCs commit to...

