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Updated: Dec 15, 2025

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

Head & neck acinar cell carcinoma: a population-based study using the seer registry.

Feiluore Yibulayin^1,2, Lei Feng¹, Meng Wang¹

¹Department of Oral & Maxillofacial Surgery and Oral Biomedical Engineering Laboratory Shanghai Stomatological Hospital, Fudan University, 356 Beijing East Road, Shanghai, 200001, People's Republic of China.

|July 10, 2020

Summary

Surgery is the only favorable prognostic indicator for head and neck acinar cell carcinoma (HNACC) survival. Gender, age, pathological grade, and TNM/AJCC stage are independent prognostic factors influencing patient outcomes.

Keywords:

Acinar cell carcinoma Head and neck Prognostic factor SEER database Survival

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Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

Area of Science:

Oncology
Head and Neck Surgery
Cancer Epidemiology

Background:

Head and neck acinar cell carcinoma (HNACC) is a rare malignancy.
Understanding its clinicopathologic characteristics, treatment, and prognostic factors is crucial for improving patient outcomes.

Purpose of the Study:

To comprehensively explore the clinicopathologic characteristics, treatment modalities, and prognostic factors of head and neck acinar cell carcinoma (HNACC).
To identify independent predictors of survival for patients diagnosed with HNACC.

Main Methods:

A population-based study utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database (1975-2016).
Kaplan-Meier analysis and Cox multivariate regression were employed to compare overall survival (OS) and HNACC-specific survival based on clinicopathologic variables.

Main Results:

A cohort of 2624 primary HNACC cases was analyzed, with a majority originating from salivary glands (2416 cases).
Surgery demonstrated a favorable association with improved disease-specific survival (DSS) and OS.
Independent prognostic factors for survival included gender, age, pathological grade, and TNM/AJCC stage.

Conclusions:

Surgical intervention emerged as the sole favorable prognostic indicator for both DSS and OS in HNACC patients.
Demographic and disease-specific factors such as gender, age, pathological differentiation, and TNM/AJCC stage significantly influence survival outcomes.