Related Experiment Video

Updated: Dec 15, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

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Advances in targeting acquired resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors

Justin A Chen1, Jonathan W Riess1

  • 1Department of Internal Medicine, Division of Hematology and Oncology, UC Davis School of Medicine and UC Davis Comprehensive Cancer Center, Sacramento, CA, USA.

Journal of Thoracic Disease
|July 10, 2020
PubMed

Insights

Next-generation sequencing advances lung cancer diagnostics and therapies. This review details acquired resistance mechanisms to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and strategies to overcome them.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Next-generation sequencing (NGS) transformed lung cancer diagnostics and treatment.
  • Epidermal growth factor receptor (EGFR) mutations drive advanced lung cancer, enabling targeted therapy with tyrosine kinase inhibitors (TKIs).

Purpose of the Study:

  • To review acquired resistance mechanisms to EGFR-TKI therapy in lung cancer.
  • To highlight recent therapeutic strategies for overcoming acquired resistance.

Main Methods:

  • Literature review of studies on EGFR-TKI resistance in lung cancer.
  • Analysis of current therapeutic approaches and emerging strategies.

Main Results:

  • Acquired resistance is a significant limitation to EGFR-TKI efficacy.
  • Various molecular mechanisms contribute to acquired resistance.
  • Novel therapeutic strategies are being developed to address resistance.

Conclusions:

  • Understanding EGFR-TKI resistance mechanisms is crucial for improving patient outcomes.
  • Targeted therapies and combination strategies show promise in overcoming resistance.
Keywords:
Lung neoplasmscarcinomadrug resistancenon-small cell lungprotein kinase inhibitorsreceptor, epidermal growth factor

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