Related Experiment Video

Updated: Dec 15, 2025

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.3K

Delivery strategies for macromolecular drugs in cancer therapy

Qin Guo1, Chen Jiang1

  • 1Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.

Acta Pharmaceutica Sinica. B
|July 10, 2020
PubMed

Keywords:
CHOL, cholesterolCP, Cas9-sgRNA plasmidCTCs, circulating tumor cellsCTLA4, cytotoxic T lymphocyte antigen 4Cancer therapyChiP, multifunctional chimeric peptideDDS, drug delivery systemsDOPE, dioleoyl phosphoethanolamineDOTAP, (2,3-dioleoyloxy-propyl)-trimethylammoniumDPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholineDelivery strategiesEMT, epithelial-to-mesenchymal transitionExosomesGOx, glucose oxidaseGRVs, glucose-responsive vesiclesLFA-1, lymphocyte function antigen-1MDP, muramyl dipeptideMFT, mifamurtideMacromolecular drugsMembrane-camouflage systemsNLR, domain-like receptorsPAMAM, polyamidoaminePD1, programmed cell death protein 1PDT, photodynamic therapyPEG, polyethylene glycolPEI, polyethyleniminePGE2, prostaglandin E2PMAPs, pathogen associated molecular patternsRBC, red blood cellsTAT, human immunodeficiency virus-1 transcription activatorTLR, toll-like receptorsTME, tumor microenvironmentTRAIL, tumor necrosis factor related apoptosis-inducing ligandaPDL1, antibodies against PDL1rFljB, recombinant flagellin

More Related Videos

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

10.0K
Manufacture and Drug Delivery Applications of Silk Nanoparticles09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.4K

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
635
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
652
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K