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Updated: Dec 15, 2025

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Deep brain stimulation and eye movements.

Maja Klarendic¹, Diego Kaski²

¹Neurological Department, University Clinical Center Ljubljana, Ljubljana, Slovenia.

The European Journal of Neuroscience

|July 10, 2020

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) impacts eye movements differently based on stimulation site and condition. Further research is needed to understand these oculomotor effects, especially for less common DBS targets.

Keywords:

basal ganglia deep brain stimulation eye movements neuroophtalmology saccades

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Area of Science:

Neuroscience
Neurology
Ophthalmology

Background:

Deep brain stimulation (DBS) is primarily used for movement disorders but increasingly for neurological and psychiatric conditions.
Oculomotor function is significantly affected by DBS, with effects varying by stimulation location and treated pathology.
Understanding DBS's impact on eye movements is crucial due to the extensive neural network overlap.

Purpose of the Study:

To review the effects of DBS on oculomotor function across various diseases.
To explore how different DBS targets influence eye movement circuits and visual outcomes.
To discuss experimental targets, unilateral vs. bilateral stimulation, and hemispheric asymmetry in eye movement control.

Main Methods:

Review of existing literature on DBS and its effects on oculomotor control.
Analysis of how stimulation parameters and electrode placement influence eye movements.
Discussion of methodological variations contributing to contradictory findings.

Main Results:

DBS affects eye movements through interference with established oculomotor circuits.
Oculomotor and visual effects are dependent on stimulation location and underlying disease.
Variability in findings is linked to methodological differences, medication status, and electrode placement.

Conclusions:

DBS has diverse effects on eye movements, necessitating careful consideration of stimulation parameters and targets.
Further investigation into less common DBS targets is required to fully elucidate their impact on ocular motility.
DBS offers insights into neural circuits governing complex eye movement control.