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Related Concept Videos

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Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
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Introduction to Horizontal Curves01:19

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Horizontal curves are essential in highway and railroad design, ensuring smooth and safe transitions between straight path segments, or tangents. These curves allow vehicles to maintain speed without abrupt changes, minimizing accidents and improving travel efficiency.A horizontal curve is typically defined by its geometric relationship to two tangents that meet at an intersection point (P.I.), where a simple curve is introduced to connect them. The back tangent refers to the initial tangent...
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A horizontal curve is characterized by its radius, intersection angle, and stationing of key points. In this case, the radius is 400 meters, and the angle of intersection is 30 degrees, with the station of the point of curvature (P.C.) at 0 + 150 meters. The goal is to determine the station values at the point of intersection (P.I.), point of tangency (P.T.), and midpoint of the curve, as well as the length of the long chord.The process begins with calculating the tangent distance (T) and the...
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
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Clinical Trials01:16

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Related Experiment Video

Updated: Dec 15, 2025

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TRICALS: creating a highway toward a cure.

Ruben P A van Eijk1,2, Tessa Kliest1, Christopher J McDermott3

  • 1Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
|July 10, 2020
PubMed
Summary

Developing new treatments for amyotrophic lateral sclerosis (ALS) requires a collaborative approach. The Treatment Research Initiative to Cure ALS (TRICALS) aims to improve drug development by addressing key challenges in clinical trials.

Keywords:
Clinical trial designbiomarkersguidelinespreclinical

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Area of Science:

  • Neuroscience
  • Clinical Pharmacology
  • Drug Development

Background:

  • Amyotrophic lateral sclerosis (ALS) drug development needs significant improvements to increase treatment efficacy.
  • The Treatment Research Initiative to Cure ALS (TRICALS) was established to foster collaboration between academia, industry, and patient groups.

Purpose of the Study:

  • To consolidate drug development paths and identify key areas for innovation in ALS clinical trials.
  • To facilitate collaborative discussions among stakeholders to accelerate the development of effective ALS therapies.

Main Methods:

  • Convening meetings with representatives from academia, patient advocacy groups, industry, and funding bodies.
  • Addressing five critical topics in ALS clinical trials: preclinical research, biomarker development, eligibility criteria, efficacy endpoints, and innovative trial design.

Main Results:

  • There is a strong consensus among stakeholders for collaborative efforts and fundamental changes in ALS drug development.
  • Industry partners are willing to adopt innovations in biomarker development, trial design, and patient selection.
  • A significant need exists for regulatory discussions and guideline amendments to support innovation in clinical trials.

Conclusions:

  • Collaborative initiatives like TRICALS are essential for advancing ALS drug development.
  • Adopting innovations in trial design, biomarkers, and patient selection can expedite the delivery of effective therapies.
  • Regulatory alignment is crucial for the successful implementation of novel approaches in future ALS clinical trials.