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The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
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A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
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Grape seed extract-soluplus dispersion and its antioxidant activity.

R Rajakumari1,2, Tatiana Volova2, Oluwatobi Samuel Oluwafemi3,4

  • 1International and Inter-University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, India.

Drug Development and Industrial Pharmacy
|July 10, 2020
PubMed
Summary

Grape seed extract nanodispersions were formulated using freeze-drying, showing excellent antioxidant activity and stability. These formulations hold promise for preventing and treating free radical-related diseases.

Keywords:
Grape seed extractantioxidantdispersionfreeze-dryingproanthocyanidinssoluplus

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Area of Science:

  • Pharmacology and Pharmaceutical Sciences
  • Materials Science
  • Food Science

Background:

  • Grape seed extract (GSE) is rich in proanthocyanidins (PCs), potent antioxidants.
  • Developing stable nanodispersion formulations enhances the bioavailability and efficacy of natural compounds like GSE.
  • Understanding the release profile and antioxidant potential is crucial for therapeutic applications.

Purpose of the Study:

  • To formulate a stable nanodispersion of grape seed extract (GSE) using Soluplus (SOLU).
  • To analyze the in-vitro release profile of the nanodispersion.
  • To evaluate the antioxidant potential of the prepared GSE nanodispersion formulations.

Main Methods:

  • Nanodispersion formulation via freeze-drying of GSE and Soluplus (SOLU).
  • Morphological characterization using Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM).
  • In-vitro release studies in simulated intestinal fluid (SIF) and antioxidant activity assays (DPPH, ABTS, FRAP, peroxidation inhibition).

Main Results:

  • Formulation FIII (1:5 ratio) demonstrated high loading efficiency (95.36%), small particle size (69.90 nm), and excellent stability (PDI: 0.154, Zeta potential: -82.10 mV).
  • The GSE-SOLU nanodispersion exhibited significant antioxidant efficiency (96.7% by DPPH).
  • Dose-dependent free radical scavenging activity was observed in ABTS and FRAP assays, with FIII showing 66.14% inhibition in the linoleic model.

Conclusions:

  • The enhanced antioxidant activity is attributed to the high content of monomeric, dimeric, and oligomeric procyanidins and phenolic groups in GSE.
  • The developed nanodispersion formulation is stable and possesses significant antioxidant properties.
  • GSE is a valuable source of PCs with potential applications in preventing and treating free radical-related diseases.