Genetic polymorphisms in interleukin-6 and interleukin-1-beta were associated with dental caries and gingivitis

Evaluate the association between single nucleotide polymorphisms (SNPs) in Interleukin-6 (IL-6) gene (rs1800795) and in Interleukin-1-beta (IL-1β) gene (rs1143627 and rs1143629) with dental caries and gingivitis in Brazilian children.

Three hundred and fifty-three children aged 8-11 years were included. Visible biofilm and gingival bleeding were evaluated by Community Periodontal Index. The International System for Detection and Assessment of Carious Lesions (ICDAS) was used to investigate dental caries. Real-time PCR evaluated SNPs in the DNA. Chi-square test, haplotype analysis and logistic regression were applied (alpha of 5%).

The GG genotype in rs1800795 (IL-6) decreases the risk of gingivitis in a co-dominant model (p = .05; OR = 0.64). The GG genotype in rs1143627 (IL-1β) reduces the risk of dental caries (Co-dominant model: ICDAS₀ versus ICDAS_1-6: p = .05; OR = 0.55. ICDAS_0-2 versus ICDAS_3-6: p = .02; OR = 0.49. Recessive model: ICDAS₀ versus ICDAS_1-6: p = .005; OR = 0.48. ICDAS_0-2 versus ICDAS_3-6: p = .004; OR = 0.45. Logistic regression: ICDAS_0-2 versus ICDAS_3-6: p = .05; OR = 0.24; CI 95%= 0.05-1.00). The GG genotype in rs1143629 was more frequent in ICDAS₀ (p = .05; OR: 0.60). In the haplotype analysis, IL-1β was associated with gingivitis.

The rs1800795 in IL-6 gene was associated with gingivitis. The rs1143627 and rs1143629 in IL-1β were associated with dental caries and gingivitis.