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Intracellular picrotoxin blocks pentobarbital-gated Cl- conductance
N Inomata1, N Tokutomi, Y Oyama
1Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Neuroscience Research
|October 1, 1988
Abstract:
Using the 'inside-out' configuration of frog sensory neurons, we studied the effect of intracellular picrotoxin on the pentobarbital-gated single channel response of Cl- -current (iCl). The pentobarbital-induced iCl showed no voltage-dependency and the single channel conductance (gamma Cl) was 16 +/- 3.1 pS (n = 6). Picrotoxin caused the pentobarbital-gated Cl- channels to react in a flickering pattern and then finally caused them to cease their opening altogether. This inhibitory action of picrotoxin was reversible.