The Treatment Models for Adenoviral Keratoconjunctivitis in the Childhood Population
1Department of Ophthalmology, University of Health Sciences Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
Insights
Povidone-iodine (PVP-I) 2.5% conjunctival irrigation effectively treats childhood adenoviral conjunctivitis. This treatment demonstrated faster symptom improvement compared to other therapies, offering a promising therapeutic option.
Area of Science:
- Ophthalmology
- Pediatrics
- Infectious Diseases
Background:
- Adenoviral conjunctivitis (AK) is a common, contagious eye infection in children.
- Effective and safe treatment options for AK are crucial to reduce symptom duration and transmission.
- Current treatments vary, necessitating research into efficacy.
Purpose of the Study:
- To evaluate the effectiveness of different treatments for adenoviral conjunctivitis in pediatric patients.
- To compare the clinical outcomes of various therapeutic agents used in treating AK.
- To identify the most effective treatment for improving AK symptoms in children.
Main Methods:
- Fifty children diagnosed with adenoviral keratoconjunctivitis (AK) were enrolled.
- Patients were categorized into four groups based on prior medical treatments.
- Clinical AK symptoms were scored and analyzed; diagnoses were confirmed via lateral flow immunoassay.
Main Results:
- The study included 50 pediatric patients (48% female, 52% male) with a mean age of 12.88 years.
- Conjunctival irrigation with 2.5% Povidone-iodine (PVP-I) showed significantly faster clinical improvement (p < 0.05) compared to other treatment groups.
- Ganciclovir ophthalmic gel 0.15% showed a non-statistically significant trend towards enhancing the efficacy of 2.5% PVP-I.
Conclusions:
- Conjunctival irrigation with 2.5% Povidone-iodine (PVP-I) is a highly effective treatment for adenoviral conjunctivitis in children.
- PVP-I irrigation offers a rapid and effective therapeutic approach for pediatric AK.
- While Ganciclovir may offer adjunctive benefits, 2.5% PVP-I irrigation is the primary driver of improved outcomes.
Abstract:
Purpose: To examine the effects of treatments performed on children with adenoviral conjunctivitis.Methods: 50 children with Adenoviral keratoconjunctivitis (AK) were evaluated. Patients were divided into four groups according to the medical treatment agents that were used previously. AK symptoms were clinically scored and analyzed. The diagnosis of all children was confirmed by an in-office lateral flow immunoassay.Results: Fifty patients with AK were included in the study. 24 (48%) were female and 26 (52%) were male. The mean age was 12.88 ± 2.66 (8-17). In PVP-I groups clinical findings shows faster improvement than other groups (p < .05).Conclusions: Conjunctival irrigation with 2.5% PVP-I is very effective for the treatment of adenoviral conjunctivitis in childhood. Ganciclovir ophthalmic gel 0.15% increases the effect of 2.5% PVP-I on AK, but this was not statistically significant.
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