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Related Concept Videos

Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

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The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
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Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
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A neuromuscular-based analysis of the open payments program.

Yohei Harada1, Sen Sheng1, Vaishali A Thombre2

  • 1Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

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|July 10, 2020
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Industry payments to neuromuscular neurologists significantly increased over five years, with a few physicians receiving the majority of funds. New treatments may be driving this trend.

Keywords:
clinicalhealth economicsneuromuscularneuromuscular disorderopen payment

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Area of Science:

  • Neurology
  • Health Economics
  • Pharmaceutical Industry

Background:

  • The Centers for Medicare and Medicaid Services (CMS) Open Payments Program (OPP) began publicly disclosing industry payment data in 2013.
  • Limited data exists on industry payments specifically to neuromuscular neurologists.

Purpose of the Study:

  • To investigate financial relationships between the pharmaceutical industry and US neuromuscular neurologists.
  • To analyze trends in industry payments from 2014 to 2018.

Main Methods:

  • Utilized the CMS OPP database to identify and quantify payments.
  • Analyzed payment data for US neuromuscular neurologists between January 2014 and December 2018.

Main Results:

  • Total annual industry payments to neuromuscular neurologists increased more than sixfold during the study period.
  • A concentration of payments was observed, with the top 10% of physicians receiving 80-90% of total payments (excluding 2014).
  • In 2018, nusinersen, vortioxetine, eteplirsen, alglucosidase alpha, edaravone, and intravenous immunoglobulin were the most common drugs associated with payments.

Conclusions:

  • The significant rise in industry payments suggests a growing financial relationship between pharmaceutical companies and neuromuscular neurologists.
  • The development of novel therapeutics, potentially including gene therapy, is a likely driver for increased industry funding in neurology.